David A Tice Selected Research

pyrrolo(2,1-c)(1,4)benzodiazepine

1/2019	Improved Therapeutic Window in BRCA-mutant Tumors with Antibody-linked Pyrrolobenzodiazepine Dimers with and without PARP Inhibition.
10/2018	Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody-Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer.
5/2017	5T4-Targeted Therapy Ablates Cancer Stem Cells and Prevents Recurrence of Head and Neck Squamous Cell Carcinoma.

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David A Tice Research Topics

Disease

28	Neoplasms (Cancer) 01/2022 - 04/2002
5	Breast Neoplasms (Breast Cancer) 01/2021 - 05/2004
3	Multiple Myeloma 01/2022 - 12/2018
2	Prostatic Neoplasms (Prostate Cancer) 10/2018 - 01/2011
2	Squamous Cell Carcinoma of Head and Neck 05/2017 - 01/2016
2	Carcinoma (Carcinomatosis) 01/2017 - 09/2009
2	Ovarian Neoplasms (Ovarian Cancer) 12/2009 - 09/2009
1	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2021
1	Triple Negative Breast Neoplasms 01/2019
1	Hematologic Neoplasms (Hematological Malignancy) 12/2018
1	Necrosis 01/2018
1	Malignant Mesothelioma 01/2018
1	Carcinogenesis 01/2016
1	Head and Neck Neoplasms (Head and Neck Cancer) 01/2016
1	Lymphoma (Lymphomas) 12/2014
1	Melanoma (Melanoma, Malignant) 04/2010
1	Weight Loss (Weight Reduction) 12/2009
1	Pathologic Processes 12/2006
1	Neoplasm Metastasis (Metastasis) 12/2006

Drug/Important Bio-Agent (IBA)

8	Immunoconjugates (Immunoconjugate)IBA 01/2019 - 11/2008
8	Monoclonal AntibodiesIBA 01/2016 - 10/2006
4	LigandsIBA 01/2018 - 01/2011
4	etaracizumabIBA 04/2010 - 10/2006
3	Biomarkers (Surrogate Marker)IBA 01/2022 - 04/2010
3	bis(3- bis(4- chlorophenyl)methyl- 4- dimethylaminophenyl)amineIBA 01/2022 - 12/2018
3	Pharmaceutical PreparationsIBA 01/2021 - 04/2002
3	pyrrolo(2,1-c)(1,4)benzodiazepineIBA 01/2019 - 05/2017
3	AntigensIBA 10/2018 - 01/2017
3	AntibodiesIBA 01/2016 - 11/2008
3	Phosphotransferases (Kinase)IBA 01/2016 - 05/2004
3	EphA2 ReceptorIBA 01/2011 - 12/2007
3	Integrin alphaVbeta3IBA 12/2009 - 10/2006
2	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 10/2018
2	Histones (Histone)IBA 01/2021 - 10/2018
2	Small Interfering RNA (siRNA)IBA 01/2021 - 06/2015
2	TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA 01/2019 - 07/2013
2	Death Domain ReceptorsIBA 01/2019 - 01/2018
2	MEDI0641IBA 05/2017 - 01/2017
2	Interleukin-6 (Interleukin 6)IBA 01/2016 - 01/2016
2	tyrosine receptor (receptor, tyrosine)IBA 01/2016 - 01/2011
2	IntegrinsIBA 01/2011 - 10/2006
2	Phenylalanine (L-Phenylalanine)FDA Link 09/2009 - 11/2008
1	Caspase 8 (Caspase-8)IBA 01/2022
1	CASP8 and FADD-Like Apoptosis Regulating Protein (FLIP-S)IBA 01/2022
1	B-Cell Maturation AntigenIBA 01/2022
1	Chimeric Antigen ReceptorsIBA 01/2022
1	RNA Helicases (RNA Helicase)IBA 01/2021
1	ceralasertibIBA 01/2021
1	Proteins (Proteins, Gene)FDA Link 01/2021
1	CaspasesIBA 01/2019
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2019
1	Brentuximab VedotinIBA 01/2019
1	Gemtuzumab (Mylotarg)FDA Link 01/2019
1	Ado-Trastuzumab EmtansineIBA 01/2019
1	Inotuzumab OzogamicinIBA 01/2019
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2019
1	TNF-Related Apoptosis-Inducing LigandIBA 01/2019
1	MEDI3726IBA 10/2018
1	glutamate carboxypeptidaseIBA 10/2018
1	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 05/2018
1	Deubiquitinating EnzymesIBA 01/2018
1	A-Form DNA (A-DNA)IBA 05/2017
1	Cytotoxins (Cytolysins)IBA 01/2017
1	CytokinesIBA 01/2016
1	Gefitinib (Iressa)FDA Link 01/2016
1	Trastuzumab (Herceptin)FDA Link 01/2016
1	Immunoglobulin G (IgG)IBA 01/2016
1	Cetuximab (Erbitux)FDA Link 07/2015
1	Membrane Proteins (Integral Membrane Proteins)IBA 06/2015
1	Amino Acid Transport Systems (Amino Acid Transporter)IBA 06/2015
1	Carbonic Anhydrase IXIBA 06/2015
1	IgA receptor (protein B)IBA 12/2014
1	Phosphoprotein Phosphatases (Phosphatases, Protein)IBA 01/2011
1	Ephrin-A1 (Ephrin A1)IBA 01/2011
1	EphrinsIBA 01/2011
1	Biological ProductsIBA 04/2010
1	Paclitaxel (Taxol)FDA LinkGeneric 12/2009
1	Bevacizumab (Avastin)FDA Link 12/2009
1	taxaneIBA 12/2009
1	Integrin beta3 (GPIIIa)IBA 12/2009
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2009
1	auristatinIBA 09/2009
1	Caspase 7IBA 11/2008
1	Caspase 3 (Caspase-3)IBA 11/2008
1	cyclenIBA 12/2007
1	Chelating AgentsIBA 12/2007
1	AcidsIBA 12/2007
1	1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidIBA 12/2007
1	AgarIBA 05/2004
1	beta CateninIBA 04/2002
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 04/2002
1	RNA (Ribonucleic Acid)IBA 04/2002

Therapy/Procedure

7	Therapeutics 05/2017 - 10/2006
4	Drug Therapy (Chemotherapy) 01/2018 - 09/2009
1	Castration 10/2018